In the NWO open program CONQUEST, we aim to improve treatment and, therefore, both lifespan and quality of life of Multiple Myeloma (MM) patients. Through the development, application, and combination of advanced computational and experimental tools we will propose novel treatment strategies.
Postdoc in Conquering Therapy Resistance in Multiple Myeloma using Advanced Computational Tools
Working at the UvA
Join us!
MM is the second-most common hematological cancer, with a rising incidence in the increasingly aging population, as MM is most prevalent in the elderly. Despite the development of novel therapies that have improved survival, MM still has a dismal prognosis because MM cells become insensitive to the administered drug (treatment resistance). Recent studies have indicated that alternative drug combinations and treatment schemes can circumvent or delay the development of treatment resistance in cancer. However, the design of such treatment schemes is difficult for various reasons.
CONQUEST combines methods from mathematics, computer science and experimental research to enable the development of such treatment schemes.
You will work on the development of computational models and will collaborate with the Amsterdam UMC for the experimental work. You will develop a MM specific computational model for (aberrant) molecular pathways based on a pre-existing pan-cancer model, and integrate this with an evolutionary game-theoretic cell population model to optimize treatment timing and dosing through optimal control and game theory.
This project will be in close cooperation with Dr. Jeroen Guikema, Dr. Katerina Stankova and Prof. Antoine van Kampen. You will be embedded in the Biosystems Data Analysis Group at the Swammerdam Institute of Life Sciences (UvA). Part of the work will be done at the TUDelft and at the Amsterdam UMC.